Messi will return to training with Barca later this week, and the club expect him to be available for Saturday's trip to Sevilla. He has yet to make a decision on his Argentina future but would be 35 by the time of the 2022 World Cup in Qatar.
Messi will have another opportunity to get his hands on the most elusive of prizes in Russian Federation this summer, but Sampaoli believes expectation levels are already spiralling out of control. Argentina are always a candidate for the title because of their image, their history.
This is likely to be Messi's last chance at winning an global tournament, so it is vital that preparations run smoothly for him and his country.
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Good moment for Spain: "We're full of hope".
The country last lifted the trophy in 1986 when Diego Maradona was named player of the tournament.
Nevertheless, the occasionally feisty nature of their Clasico showdowns does not give Sampaoli any cause for concern over Messi's fitness.
Although fellow Argentine forward Paolo Dybala had previously claimed that Messi's dominance of the final third made it tough to play alongside him in the national team, the "Little Master" says the comment was not taken as an insult. "The day before the match against Italy he said he wasn't fit to play and he didn't".
"He was tested yesterday and tried again today. I don't think there will be a problem tomorrow (Tuesday)".
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"What I find negative about this type of football is that it damages even Messi", Sampaoli wrote in an excerpt that appeared in Clarin's weekend magazine, Viva. That's why I nearly never go play as a left-wing. "We are in a position where he is untouchable".
"You can't teach him anything".
"One who has kept himself for 10 years as the best player in the world alters your way of coaching", Sampaoli wrote.
Spain comes from equaling 1-1 in Düsseldorf before Germany, while Argentina beat Italy 2-0 in Manchester. On the right we can cut in and have the whole pitch in front of us. He's the best player in the world and we need to ensure that everything we do is geared towards him being comfortable.
"With me in the national team he played further out on the left, which he's not as used to".
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The ministry has threatened to take legal action against companies and individuals engaging in any unauthorised use of such data. Cambridge Analytica's office in central London .
Argentina face Spain in Madrid tonight.