Jayme Martin, a vice president and general manager of global categories, has left the company, a spokesman confirmed on Friday.
Shares of Nike, which is scheduled to report third-quarter results next Thursday, were up marginally in trading after the bell.
A Nike spokeswoman declined to provide more details on Martin's exit.
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Amazon also has spent over a decade trying to build up its AmazonFresh grocery delivery service , but so far seen limited success. In fact, such relentless endeavors have aided Walmart's US e-commerce sales to soar 23% in the fourth quarter of fiscal 2018.
President of the Nike Brand Trevor Edwards presents the company's new "Magista" football boot in Barcelona on March 6, 2014.
With Edwards out as steward of the Nike brand, the turnaround effort now falls to the other executives.
Nike is in the process of transitioning its business and will use Edwards as a consultant until August, when he will officially retire.
Edwards, 55, had been a Nike employee since 1992 and oversaw the company's worldwide sales unit, retail and e-commerce business.
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Both of them remain in critical condition and are being treated for suspected exposure to a nerve agent. It has only ever been used once by the U.S. after the September 11, 2001 attacks.
Nike said in a statement that "there has been conduct inconsistent with Nike's core values and against our code of conduct". While he has immediately resigned his position, he will continue to serve as an adviser to CEO Mark Parker to help Nike through the transitional period.
"I'd like to thank Trevor for the important role he has played for 25 years and for his significant contributions", Parker stated. With Edwards' departure, Parker said he now plans to remain in his current role through 2020, according to the report.
Parker said Nike would be reviewing the company's protocol for dealing with internal complaints, the Journal reported.
In a news release, Parker committed, for the first time, to being chairman and CEO of the company beyond 2020.
Here's the date Apple will unveil its next generation of products
The firm has used previous events to showcase new products such as the Apple HomePod speaker, new Macs and the updated iPad Pro. However, he has predicted 10.5-inch and 12.9-inch versions for iPad Pro 2018, with no mention of an 11-inch iPad Pro 3.