The crowd was animated and responsive as the opponents interrupted each other during particularly passionate moments of the debate.
"I don't even know what you're referring to", Nixon said, to which Cuomo quipped she "should really read the newspapers".
"Excuse me, can you stop interrupting", Cuomo exclaimed.
Cuomo responded that Nixon doesn't understand the challenges of leading the nation's fourth largest state and lives in a "world of fiction", while he resides in the real world where you don't just "snap your fingers" and change happens.
Cuomo says he's led the charge against the White House; Nixon said the governor hasn't fought the White House hard enough.
Ms Nixon scoffed at Mr Cuomo's depiction of himself as a fierce opponent of the president, who like the two candidates is a New York City native.
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However, Yedlin then gave away the free-kick which led to Chelsea's victor . "It meant we needed to move the ball very fast". Newcastle's 5-4-1 prevents this by having an extra man in the middle because of the back three.
The question of whether Cuomo would remain governor throughout the entire term also came up at Wednesday night's debate.
Mr Cuomo, who has been mentioned as a possible presidential candidate in 2020, said that if he is re-elected governor he will serve out his term.
Cuomo's campaign, meanwhile, released a TV ad featuring clips of Nixon praising the Democratic governor's Women's Equality Agenda and push to legalize same-sex marriage.
At one point he cited a quote Nixon had given to the New York Times, saying that she might not have run against someone like former New York Mayor Mike Bloomberg. Pressed on her plan to bring universal health care to NY, she spent 90 seconds walking through its potential fiscal impact.
Over the next hour, the governor surprised Nixon by going negative, ripping into his challenger as a phony who concealed her tax records (she has not) and would run the state into debt-driven chaos. "We don't need a corrupt, corporate Democrat in Albany as his main opposition", she said at one point. She advised anyone attending a Cuomo event "take a coat, or maybe a blanket". "Maybe you say 76 degrees and get 65 degrees instead of freezing at 50", she said.
Cuomo himself addressed the criticism that he would be abandoning his promises to the people of NY if he ran for president. Nixon herself told Refinery29 "I'll debate the governor in a parka if I have to because the people of NY deserve a debate, and insurgent, female candidates have a right to make their voices heard".
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"And you're a corporation", Cuomo said smiling.
Cuomo laid out a series of reforms he said the state should adopt to deal with Albany corruption.
Cuomo said marijuana use is a "personal decision".
"You are a corporation", said Cuomo.
"You stood up to (Trump) about as well as he stands up to (Russian President Vladimir) Putin", Nixon said.
At Long Island's Hofstra University, the two candidates engaged in an often contentious debate, which included accusations of lying on both sides.
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On Saturday, a procession will pass the Vietnam Veterans Memorial and arrive for a funeral at Washington National Cathedral. On Capitol Hill, his desk on the Senate floor was draped with a black cloth, and adorned with a bowl of white roses.