The playmaker has been confined to the bench since Solari's appointment and was even dropped from the squad for Madrid's victory away at Roma in the Champions League last week.
Now in full-time charge Solari rang the changes for this match up against modest Melilla, with the Argentine resting the likes of Thibaut Courtois, newly crowned Ballon d'Or victor Luka Modric, Gareth Bale, Sergio Ramos and Karim Benzema.
Solari also addressed Isco's Instagram post in which the attacking midfielder asked fans if he looked overweight, and took the opportunity to speak on the importance of team selection.
Turkey seeks arrest of Saudi aides over Khashoggi death
President Donald Trump has said Washington should not take action that would undermine its relationship with the kingdom. He expressed dismay that with his actions he has thrown the relation with the United States at stake here.
Midfielder Isco then extended the advantage three minutes into the second half, netting his first since September a year ago, while Vinicius Jr. scored his maiden goal for the Spanish giants as Madrid strolled into the next round easily.
Madrid's coach may have made his feelings on team selections clear in recent times, but both Isco and Asensio have stepped up to his demands.
"I'm very happy with Isco".
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In that statement, Trump vacillated on bin Salman's involvement: "maybe he did, maybe he didn't" know about the murder scheme. The Yemen legislation could set up a bitter year-end Senate floor fight over USA war powers.
Madrid went into halftime with a three-goal lead after Marco Asensio scored twice in three minutes and debutant Javi Sanchez also got on the scoresheet late in the half.
"This game let us see many players who are well and committed", Solari added. Melilla are very good, the leader of Segunda B.
Real Madrid are now fifth in the La Liga table, five points adrift of leaders Barcelona.
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Comey have been working cooperatively and I expect that'll happen", he added. Comey tweeted he was " grateful for a fair hearing " from the judge.
Real Madrid have a string of injury problems ahead of their trip to face Huesca in La Liga this Sunday afternoon.