After easing through the opening set in 26 minutes, Pliskova appeared to switch off as world number 46 Tomljanovic switched gears to win five games without reply before levelling the contest at one set apiece.
He only served two aces compared with the 11 sent down by Chardy, but Nishikori returned superbly and pressured the Frenchman's serve throughout, breaking him twice in each set.
The 2014 U.S. Open finalist served for the match at 5-1 in the third set, but Medvedev earned a temporary reprieve when he broke the Japanese player's serve to extend the match.
"I was able to return very deep and I think I put him under pressure".
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"A lot of my time is spent in the hotel lying in bed trying to conserve as much energy as I can, because whenever I step out on court there's so much I leave out there", he said.
"And despite many chances that he had, I managed to hold my serves". Of course I tried, but I felt so far away from playing good tennis.
"She helped me just to get motivated a little bit more, to get going".
In the women's tournament Karolina Pliskova recovered to blaze past Ajla Tomljanovic 6-1 1-6 6-1 and into the Brisbane International semi-finals.
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"But (Stubbs) said, "I am absolutely sure you can win this match", which gave me some confidence and belief that I can do it and that's what I did".
"I think everything was against me today".
Reigning champion Daniil Medvedev may opt to skip his Sydney International defence following a strong campaign in Brisbane.
The win is the second time that Pliskova has won the Brisbane International, thanking her Australian coach for rousing her when she was at her low point during the match.
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